RNA Details
Disease Name
cystic fibrosis
Tissue
lung
RNA Symbol
mir-101a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Dual-luciferase reporter assay; qRT-PCR; In situ Hybridization etc.
Target
Cftr
Pathway
NA
PubMed ID
Title
MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung
Year
2012
Function
The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel that plays a critical role in the lung by maintaining fluid homeostasis. Absence or malfunction of CFTR leads to Cystic Fibrosis; Chronic cigarette smoking up-regulates miR-101 and that this miRNA could contribute to suppression of CFTR in the lungs of COPD patients.